Will Ferrell

Sherlock Holmes

John C. Reilly

Dr. John Watson

Rebecca Hall

Dr. Grace Hart

Ralph Fiennes

Prof. James Moriarty

Hugh Laurie

Mycroft Holmes

Kelly Macdonald

Mrs. Hudson

Steve Coogan

Gustav

Pam Ferris

Queen Victoria

Rob Brydon

Inspector Lestrade

Lauren Lapkus

Millie

Noah Jupe

Doxy

Bella Ramsey

Flotsam

Adam Scherr

Wrestler

Michael Culkin

Judge Over

Kieran O'Brien

PC Smalls

Jorge Leon Martinez

British Soldier

Billy Jenkins

Mudfog

Gerard Monaco

Officer

Scarlet Grace

Pickle

James Eeles

Manager Mr. Petrucka

Karl Farrer

Russian Merchant

Jason Thorpe

Butler

Wolf Roth

Sigmund Freud

Ethan Rouse

Newsreader

Paddy Holland

Tough Kid

Deepak Anand

Nobleman

Hector Bateman-Harden

Young Sherlock Holmes

Daniel Fearn

The Drooling Man

Phil Hodges

Mr. Algernon Barkworth

Paul Cassidy

Charlie Chaplin

Laura Stevely

Sherlock's Mother

Russell Wilcox

The Announcer

Jamie Baughan

Titanic Captain

Martyn Mayger

Buckingham Palace Guest

Codie-Lei Eastick

Young Watson

David Stoller

Guard (Southampton)

Lilly Aspell

Urchin (uncredited)

Andrew G. Ogleby

Lower Class Citizen (uncredited)

Richard Price

Newsboy (uncredited)

Bronson Webb

Jonathan Nightingale

Billy Zane

Himself

Michael Buffer

Fight Fan #1

Sadie Newman

Jane

Ella Bright

Bridgette

Paul Bigley

Teacher #1

Sue Maund

Teacher #2

Tommy Surridge

Inky Hands

Billy Jenkins

Mud Fog

Jack Riley

Newschild

Jess Liaudin

Hangman

Martin Bishop

Priest

Bruce Buffer

Fight Fan #2

Mark Mothersbaugh

Sound

Will Ferrell

Production

Arthur Conan Doyle

Writing

Etan Cohen

Writing

Etan Cohen

Directing

Adam McKay

Production

Toby Britton

Art